How Psilocybin Rewires the Brain: The Science of Neuroplasticity TL;DR: Psilocybin promotes neuroplasticity by activating the brain’s 5-HT2A serotonin receptors, triggering BDNF and mTOR signalling pathways that stimulate dendritic spine growth, neurogenesis, and new synaptic connections. Preclinical and clinical research suggests these brain changes may underpin psilocybin’s therapeutic effects on depression, PTSD, and anxiety — […]

